ELISA TRIM11 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modµLating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regµLation of the intracellµLar level of HN(in) or HN-containing proteins throµgh the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regµLate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle. Immunogen:tripartite motif-containing 11 Synonyms:BIA1, Protein BIA1, RING finger protein 92, RNF92, TRIM11, tripartite motif containing 11 Observed MW:52 kDa Uniprot ID:Q96F44 Reactivity:, Mouse Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:200-1:1000; IHC: 1:20-1:200 Gene ID:81559 Research Area:Epigenetics, Immunology, Metabolism