ELISA TREX1 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Major cellµLar 3'-to-5' DNA exonuclease which digests single-stranded DNA(ssDNA) and double-stranded DNA(dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumµLate in the cytosol and activate the IFN-stimµLatory DNA(ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. Immunogen:three prime repair exonuclease 1 Synonyms:3 5 exonuclease TREX1, AGS1, AGS5, CRV, DKFZp434J0310, DNase III, DRN3, HERNS, TREX1 Observed MW:32 kDa Uniprot ID:Q9NSU2 Reactivity: Tested Application:ELISA, WB, IP Recommended dilution:WB: 1:200-1:1000; IP: 1:200-1:1000 Gene ID:11277 Research Area:Metabolism