ELISA TRAIP anti-
Quantity:100µg
Purification:Immunogen affinity purified
Form:liquid
Purity:?95% as determined by SDS-PAGE
Host:Rabbit
Clonality:polyclonal
Clone ID:
Isotype:IgG
Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background:E3 ubiquitin ligase acting as a negative regµLator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regµLates TLR3/4-and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellµLar antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation(By similarity)(PubMed:22945920). Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase(PubMed:26595769). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity(PubMed:24553286). The function in translesion synthesis is controversial(PubMed:26595769).
Immunogen:TRAF interacting protein
Synonyms:RNF206, TRIP
Observed MW:53 kDa
Uniprot ID:Q9BWF2
Reactivity:, Mouse
Tested Application:ELISA, WB, IHC, IF
Recommended dilution:WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100
Gene ID:10293
Research Area:Immunology, Signal Transduction
Référence interne:
FNab08924
URL de site web:
/shop/fnab08924-elisa-traip-anti-178213
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