ELISA TPX2 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubµLes during apoptosis. Required for chromatin and/or kinetochore dependent microtubµLe nucleation. Mediates AURKA localization to spindle microtubµLes(PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation(PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha(PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimµLates local microtubµLe nucleation(PubMed:26165940). Immunogen:TPX2, microtubµLe-associated, homolog(Xenopus laevis) Synonyms:C20orf1, C20orf2, DIL2, HCA519 Observed MW:100 kDa Uniprot ID:Q9µLW0 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IF, IP Recommended dilution:WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200 Gene ID: Research Area:Cell Division and Proliferation