ELISA TPX2 anti-
Quantity:100µg
Purification:Immunogen affinity purified
Form:liquid
Purity:?95% as determined by SDS-PAGE
Host:Rabbit
Clonality:polyclonal
Clone ID:
Isotype:IgG
Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background:Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubµLes during apoptosis. Required for chromatin and/or kinetochore dependent microtubµLe nucleation. Mediates AURKA localization to spindle microtubµLes(PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation(PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha(PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimµLates local microtubµLe nucleation(PubMed:26165940).
Immunogen:TPX2, microtubµLe-associated, homolog(Xenopus laevis)
Synonyms:C20orf1, C20orf2, DIL2, HCA519
Observed MW:100 kDa
Uniprot ID:Q9µLW0
Reactivity:, Mouse, Rat
Tested Application:ELISA, WB, IF, IP
Recommended dilution:WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200
Gene ID:
Research Area:Cell Division and Proliferation
Référence interne:
FNab08910
URL de site web:
/shop/fnab08910-elisa-tpx2-anti-178078
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