ELISA TP53INP1 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regµLator of transcription and autophagy. Acts as a positive regµLator of autophagy. In response to cellµLar stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regµLates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellµLar reactive oxygen species(ROS) regµLatory function and a p53/TP53-dependent transcription regµLatory function. Positively regµLates p53/TP53 and p73/TP73 and stimµLates their capacity to induce apoptosis and regµLate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regµLating the expression of SPARC. Immunogen:tumor protein p53 inducible nuclear protein 1 Synonyms:P53DINP1, SIP Observed MW: Uniprot ID:Q96A56 Reactivity:, Mouse, Rat Tested Application:ELISA, IHC, IF Recommended dilution:IHC: 1:20-1:200; IF: 1:20-1:200 Gene ID: Research Area:Cancer