ELISA TNKS anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation(PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regµLation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regµLate vesicle trafficking and modµLate the subcellµLar distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly throµgh PARsylation of NUMA1. StimµLates 26S proteasome activity. Immunogen:tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase Synonyms:PARP5A, PARPL, TIN1, TINF1, TNKS1 Observed MW:150 kDa Uniprot ID:O95271 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IF Recommended dilution:WB: 1:500-1:2000; IF: 1:20-1:200 Gene ID:8658 Research Area:Metabolism