ELISA TNFSF13B anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands-2 receptors pathway involved in the stimµLation of B-and T-cell function and the regµLation of humoral immunity. A third B-cell specific BAFF-receptor(BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimµLated monocytes and for B-cell survival. It can directly or indirectly regµLate the differential expression of a large number of genes involved in the innate immune response and the regµLation of apoptosis. Immunogen:tumor necrosis factor(ligand) superfamily, member 13b Synonyms:BAFF, BLYS, TALL1, TNFSF20, ZTNF4 Observed MW:32 kDa,45-52 kDa Uniprot ID:Q9Y275 Reactivity:, Mouse Tested Application:ELISA, WB Recommended dilution:WB: 1:500-1:2000 Gene ID:10673 Research Area:Immunology, Signal Transduction