ELISA SRGAP2 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:RAC1 GTPase activating protein(GAP) that binds and deforms membranes, and regµLates actin dynamics to regµLate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimµLates the branching of the leading process and negatively regµLates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regµLating the formation of lamellipodia and filopodia. Immunogen:SLIT-ROBO Rho GTPase activating protein 2 Synonyms:ARHGAP34, FNBP2, Formin binding protein 2, KIAA0456, SRGAP2, srGAP3 Observed MW:130 kDa Uniprot ID:O75044 Reactivity:, Mouse Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:20-1:200 Gene ID:23380 Research Area:Signal Transduction