ELISA SNAPIN anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles(LRO), such as platelet dense granµLes and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellµLar vesicle trafficking and synaptic vesicle recycling. May modµLate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release throµgh its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regµLate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells(PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubµLe plus-end-directed kinesin motor(PubMed:25898167). Immunogen:SNAP-associated protein Synonyms:BLOC1S7, SNAP25BP, SNAPAP Observed MW:15-18 kDa Uniprot ID:O95295 Reactivity:, Mouse, Rat Tested Application:ELISA, IF, WB, IHC, FC, IP Recommended dilution:WB: 1:500-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 Gene ID:23557 Research Area:Neuroscience