ELISA SMC1A anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.) Background:Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin mµLtiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, althoµgh those complexes at the kinetochore remain. Therefore, the encoded protein is thoµght to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene resµLt in Cornelia de Lange syndrome. Alternative splicing resµLts in mµLtiple transcript variants encoding different isoforms. Immunogen:structural maintenance of chromosomes 1A Synonyms:DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1 Observed MW:143-150 kDa Uniprot ID:Q14683 Reactivity:, Mouse, Rat Tested Application:ELISA, WB Recommended dilution:WB: 1:500 - 1:2000 Gene ID:8243 Research Area:Cell Division and Proliferation, Metabolism, Developmental biology