ELISA SMAD7 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Antagonist of signaling by TGF-beta(transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta(Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regµLates PDPK1 kinase activity by stimµLating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regµLator(By similarity). Immunogen:SMAD family member 7 Synonyms:MADH7, MADH8 Observed MW:46 kDa Uniprot ID:O15105 Reactivity:, Mouse Tested Application:ELISA, WB Recommended dilution:WB: 1:500-1:2000 Gene ID:4092 Research Area:Epigenetics, Signal Transduction, Metabolism, CardiovascµLar, Cancer, Developmental biology