ELISA SMAD2 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.) Background:The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modµLators that mediate mµLtiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regµLates mµLtiple cellµLar processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors throµgh its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. Immunogen:SMAD family member 2 Synonyms:MADH2, MADR2, hMAD 2, hSMAD2, JV18, JV18 1, MAD homolog 2, Mad related protein 2, Mothers against DPP homolog 2, SMAD 2, SMAD family member 2, SMAD2 Observed MW:52 kDa Uniprot ID:Q15796 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC, IF Recommended dilution:WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200 Gene ID:4087 Research Area:Epigenetics, Signal Transduction, Metabolism, CardiovascµLar, Cancer, Developmental biology, Stem Cells