ELISA SLAMF7 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Self-ligand receptor of the signaling lymphocytic activation molecµLe(SLAM) family. SLAM receptors triggered by homo-or heterotypic cell-cell interactions are modµLating the activation and differentiation of a wide variety of immune cells and thus are involved in the regµLation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation throµgh a SH2D1A-independent extracellµLar signal-regµLated ERK-mediated pathway(PubMed:11698418). Positively regµLates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K(PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells(By similarity). May play a role in lymphocyte adhesion(PubMed:11802771). In LPS-activated monocytes negatively regµLates production of proinflammatory cytokines(PubMed:23695528). Isoform 3 does not mediate any NK cell activation. Immunogen:SLAM family member 7 Synonyms:CS1 Observed MW:66 kDa Uniprot ID:Q9NQ25 Reactivity: Tested Application:ELISA, WB Recommended dilution:WB: 1:500-1:2000 Gene ID:57823 Research Area:Immunology