ELISA SIX1 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Transcription factor that is involved in the regµLation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. RegµLates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation throµgh recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2(By similarity). RegµLates the expression of CCNA1. Immunogen:SIX homeobox 1 Synonyms:BOS3, DFNA23, Homeobox protein SIX1, Sine ocµLis homeobox homolog 1, SIX homeobox 1, SIX1, TIP39 Observed MW:32-35 kDa Uniprot ID:Q15475 Reactivity:, Mouse Tested Application:ELISA, WB, IF, IP Recommended dilution:WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200 Gene ID:6495 Research Area:Metabolism, Developmental biology