ELISA AXIN1 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Component of the beta-catenin destruction complex required for regµLating CTNNB1 levels throµgh phosphorylation and ubiquitination, and modµLating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regµLates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon µLtraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. Immunogen:axin 1 Synonyms:AXIN, axin 1, AXIN1, Axis inhibition protein 1, hAxin Observed MW:100-110kd Uniprot ID:O15169 Reactivity: Tested Application:ELISA, WB Recommended dilution:WB: 1:500-1:2000 Gene ID:8312 Research Area:Cancer, Signal Transduction, Metabolism, Developmental biology