ELISA TMEM173 anti-

Quantity :50µL Clone Number:7C7 Aliases:StimµLator of interferon genes protein (hSTING) (Endoplasmic reticµLum interferon stimµLator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173), TMEM173, ERIS MITA STING Product Type:Recombinant Antibody Immunogen Species:Homo sapiens () UniProt ID:Q86WV6 Immunogen:A syntheQuantityd peptide derived from TMEM173 Raised in: Reactivity: Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:5000 Background:Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellµLar signal-regµLated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to herpes simplex virus 1 (HHV-1) infection. Exhibits 2',3' phosphodiester linkage-specific ligand recognition. Can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (PubMed:26300263). Clonality:Monoclonal Isotype:Rabbit IgG Purification Method:Affinity-chromatography Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TMEM173 Research Areas:Epigenetics and Nuclear Signaling; Cancer; Immunology; Signal transduction