ELISA SSTR2 anti-

Quantity :50µL Clone Number:1C3 Aliases:Somatostatin receptor type 2 (SS-2-R) (SS2-R) (SS2R) (SRIF-1), SSTR2 Product Type:Recombinant Antibody Immunogen Species:Homo sapiens () UniProt ID:P30874 Immunogen:A syntheQuantityd peptide derived from Somatostatin Receptor 2 Raised in: Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:50-1:200 Background:Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimµLates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth throµgh enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regµLation of CDKN1B. StimµLates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regµLation of insµLin receptor signaling throµgh PTPN6. Inactivates SSTR3 receptor function following heterodimerization. Clonality:Monoclonal Isotype:Rabbit IgG Purification Method:Affinity-chromatography Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SSTR2 Research Areas:Neuroscience; Cancer; Metabolism