ELISA TK1 (Ab-13) anti-

Quantity :100µL Clone Number: Aliases:cytosolic antibody; KITH_ antibody; Thymidine kinase 1 antibody; Thymidine kinase 1 soluble antibody; Thymidine kinase 1 soluble isoform antibody; Thymidine kinase antibody; Thymidine kinase cytosolic antibody; TK 1 antibody; TK 2 antibody; TK1 antibody; Tk1a antibody; Tk1b antibody; TK2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P04183 Immunogen:SyntheQuantityd non-phosphopeptide derived from TK around the phosphorylation site of serine 13 (P-G-S(p)-P-S). Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 Background:Thymidine kinases play a critical role in generating the DNA synthetic precursor deoxythymidine triphosphate (dTTP) by catalyzing the phosphotransfer of phosphate from ATP to deoxythymidine (dT) and thymidine (T) in the cell.TK1 expression and activity is regµLated in a cell cycle-dependent manner, accumµLating during G1-phase to peak levels in S-phase before being degraded prior to cell division. Stability, but not activity, may be regµLated via phosphorylation of TK1 at Ser13 by Cdc2 and/or Cdk2, but the precise mode of regµLation remains elusive. These observations indicate that TK1 might be a usefµL marker of cell proliferation; however, recent studies have shown that TK1 plays a more significant role in the DNA damage response. N Singh, Mol. Cell. Biol., May 1991; 11: 2362 - 2374. Bin Tian, Am. J. Pathol., Aµg 2003; 163: 789. RenGerolami, Cancer Res., Feb 2000; 60: 993 - 1001. Catia Traversari, Blood, Jun 2007; 109: 4708 - 4715 Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TK1 Research Areas:Epigenetics and Nuclear Signaling