ELISA URI1 anti-

Quantity :100µL Clone Number: Aliases:C19orf2 antibody; Chromosome 19 open reading frame 2 antibody; NNX3 antibody; NNX3 protein antibody; PPP1R19 antibody; Protein NNX3 antibody; Protein phosphatase 1 regµLatory subunit 19 antibody; RMP antibody; RMP_ antibody; RNA polymerase II subunit 5 mediating protein antibody; RNA polymerase II subunit 5-mediating protein antibody; RPB5 mediating protein antibody; RPB5-mediating protein antibody; Unconventional prefoldin RPB5 interactor 1 antibody; Unconventional prefoldin RPB5 interactor antibody; URI antibody; URI1 antibody; URI1, prefoldin-like chaperone antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O94763 Immunogen:SyntheQuantityd peptide derived from C-terminal of RMP. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100 Background:Involved in gene transcription regµLation. Acts as a transcriptional repressor in concert with the corepressor UXT to regµLate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modµLation via hepatitis B virus X protein. Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regµLation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination. Van Leuven F., Genomics 54:511-520(1998). Ota T., Nat. Genet. 36:40-45(2004). Grimwood J., Nature 428:529-535(2004). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:URI1 Research Areas:Epigenetics and Nuclear Signaling