ELISA SMURF2 anti-

Quantity :50µL Clone Number: Aliases:E3 ubiquitin-protein ligase SMURF2 antibody; EC 6.3.2. antibody; hSMURF2 antibody; MGC138150 antibody; Smad specific E3 ubiquitin ligase 2 antibody; SMAD specific E3 ubiquitin protein ligase 2 antibody; SMAD ubiquitination regµLatory factor 2 antibody; SMAD-specific E3 ubiquitin-protein ligase 2 antibody; SMUF2_ antibody; Smurf2 antibody; Ubiquitin protein ligase SMURF2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9HAU4 Immunogen:Synthetic peptide of SMURF2 Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, IHC; ELISA:1:1000-1:2000, IHC:1:25-1:100 Background:E3 ubiquitin-protein ligase SMURF2 is an enzyme that in s is encoded by the SMURF2 gene. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjµgating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SMURF2 Research Areas:Epigenetics and Nuclear Signaling;Stem cells