ELISA USP15 anti-

Quantity :50µL Clone Number: Aliases:Deubiquitinating enzyme 15 antibody; Deubiquitinating enzyme antibody; EC 3 1 2 15 antibody; KIAA0529 antibody; MGC131982 antibody; MGC149838 antibody; MGC74854 antibody; Ubiquitin Carboxy terminal Hydrolase 15 antibody; Ubiquitin carboxyl-terminal hydrolase 15 antibody; Ubiquitin specific peptidase 15 antibody; Ubiquitin specific processing protease 15 antibody; Ubiquitin Specific Protease 15 antibody; Ubiquitin thioesterase 15 antibody; Ubiquitin thiolesterase 15 antibody; Ubiquitin-specific-processing protease 15 antibody; UBP 15 antibody; UBP15 antibody; UBP15_ antibody; Unph 2 antibody; UNPH 4 antibody; Unph-2 antibody; Unph2 antibody; Unph4 antibody; USP 15 antibody; Usp15 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9Y4E8 Immunogen:Recombinant Ubiquitin carboxyl-terminal hydrolase 15 protein (1-260AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Hydrolase that removes conjµgated ubiquitin from target proteins and regµLates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regµLator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regµLates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as \\\'Lys-48\\\'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regµLate gene expression and/or DNA repair throµgh the deubiquitination of histone H2B (PubMed:24526689). Acts as an associated component of COP9 signalosome complex (CSN) and regµLates different pathways via this association: regµLates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:USP15 Research Areas:Epigenetics and Nuclear Signaling; Cell biology