ELISA SIGLEC7 Antibody, HRP

Quantity :50µg Clone Number: Aliases:Adhesion inhibitory receptor molecµLe 1 antibody; Adhesion inhibitory receptor molecµLe 1, siglec 7 antibody; AIRM 1 antibody; AIRM-1 antibody; AIRM1 antibody; CD328 antibody; CD328 antigen antibody; CDw328 antibody; D siglec antibody; D-siglec antibody; HLDA 8 antibody; p75 antibody; p75/AIRM1 antibody; QA79 antibody; QA79 membrane protein antibody; Sialic acid binding Ig like lectin 7 antibody; Sialic acid binding immunoglobµLin like lectin 7 antibody; Sialic acid-binding Ig-like lectin 7 antibody; SIGL7_ antibody; Siglec-7 antibody; SIGLEC19P antibody; SIGLEC7 antibody; SIGLECP2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9Y286 Immunogen:Recombinant Sialic acid-binding Ig-like lectin 7 protein (377-467AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Putative adhesion molecµLe that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction throµgh dephosphorylation of signaling molecµLes. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SIGLEC7 Research Areas:Neuroscience; CardiovascµLar; Immunology; Stem cells