ELISA TAOK2 Antibody, FITC

Quantity :50µg Clone Number: Aliases:1110033K02Rik antibody; B230344N16 antibody; hKFC C antibody; hKFC-C antibody; KIAA0881 antibody; Kinase from chicken homolog C antibody; MAP3K17 antibody; mKIAA0881 antibody; Prostate derived STE20 like kinase 1 antibody; Prostate derived STE20 like kinase PSK antibody; Prostate derived sterile 20 like kinase 1 antibody; Prostate-derived STE20-like kinase 1 antibody; PSK 1 antibody; PSK antibody; PSK-1 antibody; PSK1 antibody; PSK1 beta antibody; Serine/threonine protein kinase TAO2 antibody; Serine/threonine-protein kinase TAO2 antibody; TAO 1 antibody; TAO 2 antibody; TAO kinase 2 antibody; TAO1 antibody; TAO2 antibody; TAOK 2 antibody; Taok2 antibody; TAOK2_ antibody; Thousand and one amino acid protein 2 antibody; Thousand and one amino acid protein kinase antibody; UNQ2971/PRO7431 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9µL54 Immunogen:Recombinant Serine/threonine-protein kinase TAO2 protein (719-880AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubµLins. Activates the MAPK14/p38 MAPK signaling pathway throµgh the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubµLes and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellµLar domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TAOK2 Research Areas:Signal transduction