ELISA VPS4A anti-

Quantity :50µL Clone Number: Aliases:hVPS4 antibody; Protein SKD2 antibody; SKD1 antibody; SKD1 homolog antibody; SKD1A antibody; SKD2 antibody; Vacuolar protein sorting 4 homolog A antibody; Vacuolar protein sorting 4, yeast, homolog of, A antibody; Vacuolar protein sorting factor 4A antibody; Vacuolar protein sorting-associated protein 4A antibody; vacuolar sorting protein 4 antibody; VPS4 antibody; VPS4-1 antibody; Vps4a antibody; VPS4A_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9UN37 Immunogen:Recombinant Vacuolar protein sorting-associated protein 4A protein (1-120AA) Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 Background:Involved in late steps of the endosomal mµLtivesicµLar bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimµLated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission (PubMed:24814515). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:VPS4A Research Areas:Cell biology; Microbiology; Signal transduction