ELISA FZD10 anti-

Quantity :50µg Clone Number: Aliases:CD 350 antibody; CD 350 antigen antibody; CD350 antibody; Frizzled (Drosophila) homolog 10 antibody; Frizzled-10 antibody; FZ 10 antibody; Fz-10 antibody; FZ10 antibody; FZD 10 antibody; FZD10 antibody; FZD10_ antibody; FzE 7 antibody; FzE7 antibody; hFz 10 antibody; hFz10 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9µLW2 Immunogen:Recombinant Frizzled-10 protein (125-225AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 Background:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumµLation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellµLar transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:FZD10 Research Areas:Epigenetics and Nuclear Signaling; Signal transduction; Stem cells