ELISA FBXW11 anti-

Quantity :50µL Clone Number: Aliases:beta Transducin Repeat Containing Protein 2 antibody; BTRC2 antibody; BTRCP2 antibody; F-box and WD repeats protein beta-TrCP2 antibody; F-box and WD-40 Domain Protein 1B antibody; F-box Protein FBW1B antibody; F-box/WD repeat-containing protein 11 antibody; F-box/WD repeat-containing protein 1B antibody; FBW1B antibody; FBW1B_ antibody; FBXW11 antibody; FBXW1B antibody; Homologous to Slimb protein antibody; HOS antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9UKB1 Immunogen:Recombinant F-box/WD repeat-containing protein 11 protein (1-140AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Substrate recognition component of a SCF (SKP1-CµL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing throµgh S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:FBXW11 Research Areas:Cell biology