ELISA THOC5 anti-

Quantity :100µL Clone Number: Aliases:C22orf19 antibody; Chromosome 22 open reading frame 19 antibody; Fmip antibody; Fms interacting protein antibody; fSAP79 antibody; Functional spliceosome-associated protein 79 antibody; hTREX90 antibody; KIAA0983 antibody; LOC400922 antibody; NF2/meningioma region protein pK1.3 antibody; PK1.3 antibody; Placental protein 39.2 antibody; PP39.2 antibody; THO complex 5 antibody; THO complex subunit 5 antibody; THO complex subunit 5 homolog antibody; thoc5 antibody; THOC5_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13769 Immunogen:SyntheQuantityd peptide derived from internal of THOC5. Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100 Background:Acts as component of the THO subcomplex of the TREX complex which is thoµght to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probaly mediates association of the TREX and CFIm complexes. RegµLates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granµLocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development. Xie Y.G., Hum. Mol. Genet. 2:1361-1368(1993). Nagase T., DNA Res. 6:63-70(1999). Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004) Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:THOC5 Research Areas:Immunology