ELISA Snaclec rhodocytin subunit alpha Antibody, Biotin

Quantity :50µg Clone Number: Aliases:antibody; Snaclec rhodocytin subunit alpha antibody; Aggretin alpha chain antibody; Rhodoaggretin subunit alpha antibody Product Type:Polyclonal Antibody Immunogen Species:Calloselasma rhodostoma (Malayan pit viper) (Agkistrodon rhodostoma) UniProt ID:Q9I841 Immunogen:Recombinant Calloselasma rhodostoma Snaclec rhodocytin subunit alpha protein (1-136AA) Raised in:Rabbit Reactivity:Calloselasma rhodostoma Tested Applications:ELISA Background:Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen tyrosine kinase (Syk), subsequent activation of PLC-gamma-2, and platelet activation and aggregation. Binding to GPIbalpha (GP1BA) and alpha-2/beta-1 (ITGA2/ITGB1) may also induce aggregation, but this is controversial. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: Research Areas:Others