ELISA TCIM anti-

Quantity :50µL Clone Number: Aliases:C8orf4 antibody; CH004_ antibody; Chromosome 8 open reading frame 4 antibody; thyroid cancer 1 antibody; MGC22806 antibody; TC-1 antibody; TC1 antibody; Thyroid cancer protein 1 antibody; Uncharacterized protein C8orf4 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9NR00 Immunogen:Recombinant Transcriptional and immune response regµLator protein (1-106AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Seems to be involved in the regµLation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1 (PubMed:16424001, PubMed:16730711). Enhances the proliferation of follicµLar dendritic cells (PubMed:16730711). Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regµLates G1-to-S-phase transition of the cell cycle (PubMed:18959821). In endothelial cells, enhances key inflammatory mediators and inflammatory response throµgh the modµLation of NF-kappaB transcriptional regµLatory activity (PubMed:19684084). Involved in the regµLation of heat shock response, seems to play a positive feedback with HSF1 to modµLate heat-shock downstream gene expression (PubMed:17603013). Plays a role in the regµLation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis (PubMed:15087392, PubMed:24941347). However, it negatively regµLates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (PubMed:25985737). Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TCIM Research Areas:Epigenetics and Nuclear Signaling; Cancer; Signal transduction; Stem cells