ELISA TXNIP Antibody, Biotin

Quantity :50µg Clone Number: Aliases:EST01027 antibody; HHCPA78 antibody; THIF antibody; Thioredoxin binding protein 2 antibody; Thioredoxin interacting protein antibody; Thioredoxin-binding protein 2 antibody; Thioredoxin-interacting protein antibody; TXNIP antibody; TXNIP_ antibody; UpregµLated by 1,25 dihydroxyvitamin D 3 antibody; VDUP1 antibody; Vitamin D3 up-regµLated protein 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9H3M7 Immunogen:Recombinant Thioredoxin-interacting protein (299-381AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecµLe between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TXNIP Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cell biology; Metabolism; Signal transduction