ELISA KCND2 anti-

Quantity :50µL Clone Number: Aliases:KCD2 antibody; KCND 2 antibody; KCND2 antibody; KCND2_ antibody; KIAA1044 antibody; MGC119702 antibody; MGC119703 antibody; Potassium voltage gated channel Shal related subfamily member 2 antibody; Potassium voltage-gated channel subfamily D member 2 antibody; RK 5 antibody; RK5 antibody; Voltage gated potassium channel Kv4.2 antibody; Voltage gated potassium channel subunit Kv4.2 antibody; Voltage sensitive potassium channel antibody; Voltage-gated potassium channel subunit Kv4.2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9NZV8 Immunogen:Recombinant Potassium voltage-gated channel subfamily D member 2 protein (501-630AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regµLates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regµLates the frequency of repetitive action potential firing, shortens the duration of action potentials and regµLates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regµLation of the circadian rhytm of action potential firing in suprachiasmatic nucleus neurons, which regµLates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels throµgh which potassium ions pass in accordance with their electrochemical gradient (PubMed:10551270, PubMed:15454437, PubMed:14695263, PubMed:14623880, PubMed:14980201, PubMed:16934482, PubMed:24811166, PubMed:24501278). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11507158). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regµLatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modµLates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed:15454437, PubMed:14623880, PubMed:14980201, PubMed:19171772, PubMed:24501278, PubMed:24811166). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regµLates both channel characteristics and activity (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:KCND2 Research Areas:Neuroscience; CardiovascµLar