ELISA SIRT5 anti-

Quantity :50µg Clone Number: Aliases:NAD dependent deacetylase sirtuin 5 antibody; NAD dependent lysine demalonylase and desuccinylase sirtuin 5 mitochondrial antibody; NAD dependent protein deacylase sirtuin 5 mitochondrial antibody; NAD-dependent protein deacylase sirtuin-5; mitochondrial antibody; RegµLatory protein SIR2 homolog 5 antibody; Silent mating type information regµLation 2 S.cerevisiae homolog 5 antibody; Sir2 like 5 antibody; SIR2-like protein 5 antibody; SIR2L5 antibody; SIR5_ antibody; Sirt5 antibody; Sirtuin 5 antibody; Sirtuin type 5 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9NXA8 Immunogen:Recombinant NAD-dependent protein deacylase sirtuin-5, mitochondrial protein (60-212AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 Background:NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regµLation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). ModµLates ketogenesis throµgh the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SIRT5 Research Areas:Epigenetics and Nuclear Signaling; Cancer; CardiovascµLar; Metabolism