ELISA SMURF2 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:E3 ubiquitin-protein ligase SMURF2 antibody; EC 6.3.2. antibody; hSMURF2 antibody; MGC138150 antibody; Smad specific E3 ubiquitin ligase 2 antibody; SMAD specific E3 ubiquitin protein ligase 2 antibody; SMAD ubiquitination regµLatory factor 2 antibody; SMAD-specific E3 ubiquitin-protein ligase 2 antibody; SMUF2_ antibody; Smurf2 antibody; Ubiquitin protein ligase SMURF2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9HAU4 Immunogen:Recombinant E3 ubiquitin-protein ligase SMURF2 protein (1-748AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjµgating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 resµLts in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SMURF2 Research Areas:Epigenetics and Nuclear Signaling; Stem cells