ELISA SENP6 anti-

Quantity :50µg Clone Number: Aliases:2810017C20Rik antibody; FLJ11355 antibody; FLJ11887 antibody; KIAA0389 antibody; KIAA0797 antibody; SENP 6 antibody; Senp6 antibody; SENP6_ antibody; Sentrin specific protease 6 antibody; Sentrin-specific protease 6 antibody; Sentrin/SUMO specific protease SENP6 antibody; Sentrin/SUMO-specific protease SENP6 antibody; SSP 1 antibody; SSP1 antibody; SUMO 1 specific protease 1 antibody; SUMO 1 specific protease antibody; SUMO-1-specific protease 1 antibody; SUMO1 specific protease 1 antibody; SUMO1 specific protease antibody; SUMO1/sentrin specific peptidase 6 antibody; SUSP 1 antibody; SUSP1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9GZR1 Immunogen:Recombinant Sentrin-specific protease 6 protein (1-270AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IF; Recommended dilution: IF:1:50-1:200 Background:Protease that deconjµgates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjµgates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regµLating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PmL and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair throµgh homologous recombination. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SENP6 Research Areas:Epigenetics and Nuclear Signaling; Cell biology