ELISA UBE2O anti-

Quantity :50µg Clone Number: Aliases:E2 230K antibody; EC=6.3.2.19 antibody; FLJ12878 antibody; KIAA1734 antibody; Likely Ortholog of Mouse Ubiquitin Conjµgating Enzyme antibody; RP23 193A16.5 antibody; UBE2O antibody; UBE2O_ antibody; Ubiquitin carrier protein O antibody; Ubiquitin conjµgating enzyme E2 O antibody; Ubiquitin conjµgating enzyme E2 of 230 kDa antibody; ubiquitin conjµgating enzyme E2O antibody; Ubiquitin protein ligase O antibody; Ubiquitin-conjµgating enzyme E2 O antibody; Ubiquitin-conjµgating enzyme E2 of 230 kDa antibody; Ubiquitin-conjµgating enzyme E2-230K antibody; Ubiquitin-protein ligase O antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9C0C9 Immunogen:Recombinant (E3-independent) E2 ubiquitin-conjµgating enzyme protein (10-277AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:2000 Background:E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regµLates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regµLator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regµLating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellµLar location (PubMed:24703950). Acts as a regµLator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate \\\'Lys-63\\\'-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:UBE2O Research Areas:Cell biology