ELISA PINK1 anti-

Quantity :50µg Clone Number: Aliases:BRPK antibody; FLJ27236 antibody; mitochondrial antibody; PARK 6 antibody; PARK6 antibody; Phosphatase and Tensin Homolog antibody; PINK 1 antibody; PINK1 antibody; PINK1_ antibody; Protein kinase BRPK antibody; PTEN induced putative kinase 1 antibody; PTEN induced putative kinase protein 1 antibody; PTEN-induced putative kinase protein 1 antibody; Serine/threonine kinase PINK1 mitochondrial antibody; Serine/threonine protein kinase PINK1 mitochondrial antibody; Serine/threonine-protein kinase PINK1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9BXM7 Immunogen:Recombinant Serine/threonine-protein kinase PINK1, mitochondrial protein (162-272AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Protects against mitochondrial dysfunction during cellµLar stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria throµgh the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at \\\'Ser-65\\\' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fµLly-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PINK1 Research Areas:Neuroscience; Cancer; CardiovascµLar; Metabolism; Signal transduction