ELISA COPS8 Antibody, FITC

Quantity :50µg Clone Number: Aliases:COP9 homolog antibody; COP9 signalosome complex subunit 8 antibody; COP9 signalosome subunit 8 antibody; Cops8 antibody; CSN8 antibody; CSN8_ antibody; hCOP9 antibody; JAB1 containing signalosome subunit 8 antibody; JAB1-containing signalosome subunit 8 antibody; SGN8 antibody; Signalosome subunit 8 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q99627 Immunogen:Recombinant COP9 signalosome complex subunit 8 protein (150-198AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Component of the COP9 signalosome complex (CSN), a complex involved in various cellµLar and developmental processes. The CSN complex is an essential regµLator of the ubiquitin (Ubl) conjµgation pathway by mediating the deneddylation of the cµLlin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:COPS8 Research Areas:Cell biology; Developmental biology; Immunology; Signal transduction; Stem cells