ELISA UIMC1 Antibody, HRP

Quantity :50µg Clone Number: Aliases:BRCA1-A complex subunit RAP80 antibody; Nuclear zinc finger protein RAP80 antibody; OTTHUMP00000161441 antibody; OTTHUMP00000223372 antibody; OTTHUMP00000223374 antibody; RAP80 antibody; Receptor associated protein 80 antibody; Receptor-associated protein 80 antibody; Retinoid X receptor interacting protein 110 antibody; Retinoid x receptor interacting protein antibody; Retinoid X receptor-interacting protein 110 antibody; RIP110 antibody; Rxrip110 antibody; Ubiquitin interaction motif containing 1 antibody; Ubiquitin interaction motif containing protein 1 antibody; Ubiquitin interaction motif-containing protein 1 antibody; UIMC1 antibody; UIMC1_ antibody; X2HRIP110 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96RL1 Immunogen:Recombinant BRCA1-A complex subunit RAP80 protein (161-235AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds \'Lys-63\'-linked ubiquitin (PubMed:19328070, Ref.36). Plays a central role in the BRCA1-A complex by specifically binding \'Lys-63\'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes \'Lys-63\'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than \'Lys-63\'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such resµLts is however unclear in vivo. Does not bind Lys-48\'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:UIMC1 Research Areas:Epigenetics and Nuclear Signaling