ELISA TRIM11 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:BIA 1 antibody; BIA1 antibody; E3 ubiquitin protein ligase TRIM11 antibody; E3 ubiquitin-protein ligase TRIM11 antibody; Protein BIA1 antibody; RING finger protein 92 antibody; RING type E3 ubiquitin transferase TRIM11 antibody; RNF 92 antibody; RNF92 antibody; TRI11_ antibody; Trim 11 antibody; TRIM11 antibody; Tripartite motif containing 11 antibody; tripartite motif protein 11 antibody; Tripartite motif-containing protein 11 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96F44 Immunogen:Recombinant E3 ubiquitin-protein ligase TRIM11 protein (267-468AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modµLating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regµLation of the intracellµLar level of HN (in) or HN-containing proteins throµgh the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regµLate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TRIM11 Research Areas:Neuroscience; Cell biology