ELISA VP35 anti-

Quantity :50µg Clone Number: Aliases:VP35 antibody; Polymerase cofactor VP35 antibody Product Type:Polyclonal Antibody Immunogen Species:Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus) UniProt ID:Q91DE0 Immunogen:Recombinant Reston ebolavirus Polymerase cofactor VP35 protein (1-329AA) Raised in:Rabbit Reactivity:Reston ebolavirus Tested Applications:ELISA Background:Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellµLar antiviral state by blocking virus-induced phosphorylation and activation of interferon regµLatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced throµgh the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:VP35 Research Areas:Others