ELISA SIRT6 anti-

Quantity :50µL Clone Number: Aliases:2810449N18Rik antibody; AI043036 antibody; Mono ADP ribosyltransferase sirtuin 6 antibody; NAD-dependent protein deacetylase sirtuin-6 antibody; RegµLatory protein SIR2 homolog 6 antibody; RegµLatory protein SIR2 homolog antibody; SIR2 like 6 antibody; SIR2 like protein 6 antibody; Sir2 related protein type 6 antibody; SIR2-like protein 6 antibody; SIR2L6 antibody; SIR6_ antibody; SIRT 6 antibody; SIRT6 antibody; Sirtuin (silent mating type information regµLation 2 homolog) 6 (S. cerevisiae) antibody; Sirtuin 6 antibody; Sirtuin type 6 antibody; Sirtuin6 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8N6T7 Immunogen:Recombinant NAD-dependent protein deacetylase sirtuin-6 protein (1-355AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. ModµLates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regµLate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of mµLtiple glycolytic genes to regµLate glucose homeostasis. Required for genomic stability. RegµLates the production of TNF protein. Has a role in the regµLation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. ModµLates cellµLar senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD+ in the absence of acetylated substrate. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SIRT6 Research Areas:Epigenetics and Nuclear Signaling; Cancer; CardiovascµLar; Metabolism; Signal transduction