ELISA RNF139 anti-

Quantity :50µL Clone Number: Aliases:RNF139 antibody; TRC8 antibody; E3 ubiquitin-protein ligase RNF139 antibody; EC 2.3.2.27 antibody; RING finger protein 139 antibody; RING-type E3 ubiquitin transferase RNF139 antibody; Translocation in renal carcinoma on chromosome 8 protein antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8WU17 Immunogen:Recombinant E3 ubiquitin-protein ligase RNF139 protein (510-664AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:E3-ubiquitin ligase; acts as a negative regµLator of the cell proliferation throµgh mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticµLum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RNF139 Research Areas:Cancer; Cell biology