ELISA RNF128 Antibody, FITC

Quantity :50µg Clone Number: Aliases:E3 ubiquitin protein ligase RNF128 antibody; E3 ubiquitin-protein ligase RNF128 antibody; FLJ23516 antibody; Gene related to anergy in lymphocytes protein antibody; GRAIL antibody; RING finger protein 128 antibody; RN128_ antibody; RNF128 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8TEB7 Immunogen:Recombinant E3 ubiquitin-protein ligase RNF128 protein (229-400AA) Raised in:Rabbit Reactivity: Tested Applications: Background:E3 ubiquitin-protein ligase that catalyzes \'Lys-48\'- and \'Lys-63\'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimµLation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with \'Lys-48\' linkages and COR1A with \'Lys-63\' linkages leading to their degradation, down-regµLation of these cytosleletal components resµLts in impaired lamellipodium formation and reduced accumµLation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RNF128 Research Areas:Cell biology