ELISA SKA2 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:FAM33A antibody; Family with sequence similarity 33; member A antibody; FLJ12758 antibody; MGC110975 antibody; Protein FAM33A antibody; SKA 2 antibody; SKA2 antibody; SKA2_ antibody; Spindle and kinetochore associated complex subunit 2 antibody; Spindle and kinetochore associated protein 2 antibody; Spindle and kinetochore-associated protein 2 antibody; Spindle and KT (kinetochore) associated 2 antibody; Spindle and KT associated 2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8WVK7 Immunogen:Recombinant Spindle and kinetochore-associated protein 2 protein (1-121AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Component of the SKA1 complex, a microtubµLe-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubµLes leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubµLe interface and directly associates with microtubµLes as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubµLe in a depolymerization-coupled manner (PubMed:17093495, PubMed:19289083). In the complex, it is required for SKA1 localization (PubMed:19289083). Affinity for microtubµLes is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubµLes (PubMed:23085020). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SKA2 Research Areas:Cell biology