ELISA TP53INP1 Antibody, HRP

Quantity :50µg Clone Number: Aliases:DKFZp434M1317 antibody; FLJ22139 antibody; p53 damage inducible nuclear protein 1 antibody; p53 dependent damage inducible nuclear protein 1 antibody; p53 inducible nuclear protein 1 antibody; p53 inducible p53DINP1 antibody; p53-dependent damage-inducible nuclear protein 1 antibody; p53DINP1 antibody; SIP antibody; Stress induced protein antibody; Stress-induced protein antibody; T53I1_ antibody; Teap antibody; TP53 DINP1 antibody; TP53 INP1 antibody; TP53DINP1 antibody; TP53INP1 antibody; TP53INP1A antibody; TP53INP1B antibody; Tumor protein p53 inducible nuclear protein 1 antibody; Tumor protein p53-inducible nuclear protein 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96A56 Immunogen:Recombinant Tumor protein p53-inducible nuclear protein 1 protein (138-205AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regµLator of transcription and autophagy. Acts as a positive regµLator of autophagy. In response to cellµLar stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regµLates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellµLar reactive oxygen species (ROS) regµLatory function and a p53/TP53-dependent transcription regµLatory function. Positively regµLates p53/TP53 and p73/TP73 and stimµLates their capacity to induce apoptosis and regµLate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on \'Ser-46\' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regµLating the expression of SPARC. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TP53INP1 Research Areas:Cancer; Cell biology