ELISA CPEB3 Antibody, HRP

Quantity :50µg Clone Number: Aliases:CPE-binding protein 3 antibody; CPE-BP3 antibody; CPEB 3 antibody; CPEB3 antibody; CPEB3_ antibody; Cytoplasmic polyadenylation element binding protein 3 antibody; Cytoplasmic polyadenylation element-binding protein 3 antibody; hCPEB-3 antibody; KIAA0940 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8NE35 Immunogen:Recombinant Cytoplasmic polyadenylation element-binding protein 3 protein (414-525AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimµLated state but, following neuronal stimµLation, acts as a translational activator (By similarity). In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3\'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). In the basal state, binds to the mRNA 3\'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regµLates their translation (By similarity). Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity). When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity). In the basal state, suppresses SUMO2 translation but activates it following neuronal stimµLation (By similarity). Binds to the 3\'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (By similarity). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimµLation (By similarity). Negatively regµLates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed:21336257). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed:20639532). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (PubMed:26398195). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CPEB3 Research Areas:Neuroscience