ELISA USP37 Antibody, HRP

Quantity :50µg Clone Number: Aliases:Deubiquitinating enzyme 3 antibody; Deubiquitinating enzyme 37 antibody; EC 3.1.2.15 antibody; KIAA1594 antibody; MGC117261 antibody; OTTHUMP00000164146 antibody; tmp_locus_50 antibody; Ubiquitin carboxyl-terminal hydrolase 37 antibody; Ubiquitin specific peptidase 37 antibody; Ubiquitin specific processing protease 37 antibody; Ubiquitin specific protease 37 antibody; Ubiquitin thioesterase 37 antibody; Ubiquitin thiolesterase 37 antibody; Ubiquitin-specific-processing protease 37 antibody; UBP37_ antibody; USP37 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q86T82 Immunogen:Recombinant Ubiquitin carboxyl-terminal hydrolase 37 protein (671-797AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of \'Lys-11\'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of \'Lys-48\'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regµLation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:USP37 Research Areas:Epigenetics and Nuclear Signaling; Cell biology