ELISA SETX anti-

Quantity :50µg Clone Number: Aliases:ALS4 antibody; Amyotrophic lateral sclerosis 4 protein antibody; AOA2 antibody; bA479K20.2 antibody; DKFZp781B151 antibody; FLJ12840 antibody; FLJ43459 antibody; KIAA0625 antibody; Probable helicase senataxin antibody; SCAR1 antibody; SEN1 homolog antibody; Setx antibody; SETX_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q7Z333 Immunogen:Recombinant Probable helicase senataxin protein (2401-2677AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regµLation by its ability to modµLate RNA Polymerase II (Pol II) binding to chromatin and throµgh its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224). Required for the 3\' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regµLation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability throµgh the regµLation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells throµgh FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SETX Research Areas:Epigenetics and Nuclear Signaling; Neuroscience