ELISA NF2 (Ab-518) anti-

Quantity :100µL Clone Number: Aliases:ACN antibody; BANF antibody; Bilateral acoustic neuroma antibody; MERL_ antibody; Merlin antibody; Moesin ezrin radixin like protein antibody; Moesin ezrin radizin like antibody; Moesin-ezrin-radixin-like protein antibody; Neurofibromatosis 2 antibody; Neurofibromatosis type 2 antibody; Neurofibromatosis2 antibody; Neurofibromin 2 antibody; Neurofibromin-2 antibody; Neurofibromin2 antibody; NF 2 antibody; Nf2 antibody; SCH antibody; Schwannomerlin antibody; Schwannomin antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P35240 Immunogen:Peptide sequence around aa.516~520 (R-L-S-M-E) derived from Merlin. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; WB:1:500-1:1000, IHC:1:50-1:200 Background:Probable regµLator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regµLation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimµLating activity. Guang-Hui Xiao, et al. (2005) Mol. Cell. Biol ; 25: 2384 - 2394. Hi-Su Yang, et al. (2006) Cancer Res ; 66: 2708 - 2715. R Bohni, et al. (1994) J. Biol. Chem ; 269: 14541 - 14545. Adam J. Ratner, et al. (2001) J. Biol. Chem ; 276: 19267 - 19275. Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:NF2 Research Areas:Epigenetics and Nuclear Signaling?Neuroscience?Cancer;Signal transduction