ELISA TET2 anti-

Quantity :50µL Clone Number: Aliases:FLJ20032 antibody; KIAA1546 antibody; MDS antibody; Methylcytosine dioxygenase TET2 antibody; Nbla00191 antibody; Probable methylcytosine dioxygenase TET2 antibody; Protein Ayu17 449 antibody; Tet 2 antibody; Tet methylcytosine dioxygenase 2 antibody; Tet oncogene 2 antibody; Tet oncogene family member 2 antibody; TET2 antibody; TET2_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q6N021 Immunogen:Recombinant Methylcytosine dioxygenase TET2 protein (1833-2002AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regµLation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TET2 Research Areas:Epigenetics and Nuclear Signaling